id: Pfam:PF11351
pfam_id: PF11351
name: Holin of 3TMs, for gene-transfer release
short_name: GTA_holin_3TM
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11351
counters:
  proteins: 1476
  matches: 1476
  proteomes: 1335
  taxa: 2117
  structures: 0
  alphafold_models: 1007
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021497
description: This is a family of bacterial 3TM holins. In Rhodobacter capsulatus the protein is expressed
  just overlapping and downstream of a putative N-acetylmuramidase lysozyme (an endolysin) thought to
  be responsible for lysing a phage particle, RcGTA - a gene-transfer agent. A holin would be necessary
  for such an endolysin to access the peptidoglycan [[cite:PUB00075656]]. Gene-transfer agents are bacteriophage-like
  genetic elements with the sole known function of horizontal gene transfer, serving an important role
  in microbial evolution. In order to be released from the cell these require the combined action of an
  endolysin and this holin [[cite:PUB00075657]].