id: Pfam:PF11380
pfam_id: PF11380
name: Stealth protein CR2, conserved region 2
short_name: Stealth_CR2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11380
counters:
  proteins: 4740
  matches: 4777
  proteomes: 3139
  taxa: 6946
  structures: 8
  alphafold_models: 3289
  domain_architectures: 147
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021520
description: Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa
  and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD
  sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts
  and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains
  appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta.
  Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions
  in order for the bacteria to evade detection by the host innate immune system [[cite:PUB00075655]].