id: Pfam:PF11382
pfam_id: PF11382
name: Copper transport outer membrane protein, MctB
short_name: MctB
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11382
counters:
  proteins: 2374
  matches: 2398
  proteomes: 2353
  taxa: 3169
  structures: 5
  alphafold_models: 1543
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021522
description: Outer membrane channel protein MctB in Mycobacterium tuberculosis is part of a Cu resistance
  mechanism that ensures low intracellular Cu levels in the bacterium. Human resistance to bacteria, mediated
  via IFN-gamma-mediated activation of macrophages, may involve the use of reactive Cu(1) in the presence
  of hydrogen peroxide, since activated Cu is toxic to bacteria. IFN-gamma stimulates the trafficking
  of the Cu transporter ATP7a to the vesicles that fuse with phagosome and these phagosomes are found
  to have a high Cu content and an increased bactericidal activity against E.coli. Using MctB, Mycobacterium
  tuberculosis may limit the amount of excess Cu within it whole in the host [[cite:PUB00075654]].