id: Pfam:PF11459
pfam_id: PF11459
name: Transcriptional regulator, AbiEi antitoxin, Type IV TA system
short_name: AbiEi_3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11459
counters:
  proteins: 1179
  matches: 1179
  proteomes: 1071
  taxa: 2060
  structures: 0
  alphafold_models: 780
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021561
description: AbiEi_3 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial
  abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi
  system is activated upon infection with phage to abort the cell thus preventing the spread of phage
  through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded
  lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the
  plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread
  in bacteria and archaea. The cognate antitoxin is [pfam:PF13338] [[cite:PUB00075538]].