id: Pfam:PF11503
pfam_id: PF11503
name: YNR034W-A-like
short_name: YNR034W-A-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11503
counters:
  proteins: 68
  matches: 68
  proteomes: 49
  taxa: 104
  structures: 5
  alphafold_models: 59
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021591
description: This family of proteins is predominantly found in Saccharomycetales, including YNR034W-A
  (also known as Ego4) and YCR075W-A (Ego2) from Saccharomyces cerevisiae. Ego2 is a component of the
  yeast EGO complex (EGOC), which is responsible for the amino acid-dependent activation of the target
  of rapamycin complex 1 (TORC1). Ego2 adopts a Roadblock domain fold that consists of a central core
  beta-sheet of five anti-parallel beta-strands flanked by a long alpha-helix on the bottom side. Ego4
  shows a similar configuration. It interacts with the GTPase Gtr2, but its specific function remains
  unknown [[cite:PUB00100978],[cite:PUB00100979]].