id: Pfam:PF11615
pfam_id: PF11615
name: CCR4-associated factor 4
short_name: Caf4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11615
counters:
  proteins: 17
  matches: 17
  proteomes: 15
  taxa: 51
  structures: 1
  alphafold_models: 14
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021653
description: Caf4 is a WD40 repeats containing protein involved in mitochondrial fission. It displays
  physical interactions with CCR4-NOT complex [[cite:PUB00053527]]. It has a paralogue, Mdv1. Both Caf4
  and Mdv1 act as adapter proteins, binding to Fis1 on the mitochondrial outer membrane and recruiting
  the dynamin-like GTPase Dnm1 to form mitochondrial fission complexes [[cite:PUB00053320]]. However,
  Fis1 and Caf4, but not Mdv1, determine the polar localization of Dnm1 clusters on the mitochondrial
  surface [[cite:PUB00074937]].