id: Pfam:PF11623
pfam_id: PF11623
name: NAD(P)H dehydrogenase subunit S
short_name: NdhS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11623
counters:
  proteins: 721
  matches: 721
  proteomes: 581
  taxa: 1686
  structures: 12
  alphafold_models: 546
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021659
description: This family is found in Bacteria and Streptophyta includes members such as NdhS (NAD(P)H-quinone
  oxidoreductase subunit S). NdhS, also known as CRR31 (chlororespiratory reduction 31), is a subunit
  of the chloroplast NADH dehydrogenase-like (NDH) complex [[cite:PUB00083363]]. It is also a subunit
  of the cyanobacterial NDH-1 complex [[cite:PUB00083366]] [[cite:PUB00083365]]. NAD(P)H-oxidizing subunits
  have not been found in chloroplasts or cyanobacteria, where ferredoxin is probably the electron donor.
  NdhS contributes to the formation of a ferredoxin binding site of NDH [[cite:PUB00083363]] and is necessary
  for high affinity binding of ferredoxin [[cite:PUB00083368]]. The cyanobacterial NDH-1 complex, also
  known as NADPH:plastoquinone oxidoreductase or type I NAD(P)H dehydrogenase, is involved in plastoquinone
  reduction and cyclic electron transfer (CET) around photosystem I. The chloroplast NDH is more similar
  to cyanobacterial NDH-1, which is believed to be the origin of chloroplast NDH, than to mitochondrial
  NADH dehydrogenase present in the same species [[cite:PUB00083364]] [[cite:PUB00083367]]. The NDH complexes
  of chloroplasts, however, contain many subunits that are absent from cyanobacterial NDH-1 complexes.