id: Pfam:PF11779
pfam_id: PF11779
name: Small subunit of serine palmitoyltransferase-like
short_name: SPT_ssu-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11779
counters:
  proteins: 4017
  matches: 4022
  proteomes: 2398
  taxa: 6530
  structures: 21
  alphafold_models: 3505
  domain_architectures: 41
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024512
description: Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis.
  In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance
  the activity of SPT, conferring full enzyme activity upon it [[cite:PUB00056204]]. The 2 ssSPT isoforms
  share a conserved hydrophobic central domain, which is predicted to reside in the membrane.