id: Pfam:PF11797
pfam_id: PF11797
name: WxL Interacting Protein, host binding domain
short_name: WxLIP_HBD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11797
counters:
  proteins: 1977
  matches: 1977
  proteomes: 547
  taxa: 818
  structures: 2
  alphafold_models: 1270
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021759
description: 'This domain (previously known as DUF3324) is found in WxL interacting proteins (WxLIP) which
  play a role in virulence and are widely distributed in firmicutes. The WxL proteins usually occur within
  a gene cluster that contains two WxL proteins and a WxL interacting protein composed of three domains:
  peptidoglycan binding domain (PGBD), host binding domain (HBD), and transmembrane helix (TMH). The domain
  represented by this entry is likely to interact with proteins on the surface of eukaryotic host endothelial
  cells. This HBD domain is frequently found in combination with PGBD domain ([pfam:PF06030]) and both
  were shown to function synergistically as a single unit that binds to the peptidoglycan and interacts
  with the eukaryotic host [[cite:PUB00154331]]. The HBD domain is predicted to adopt a beta-sandwich
  with an Ig-like topology.'