id: Pfam:PF11822
pfam_id: PF11822
name: SANT and BTB domain regulator of CSR, BTB domain
short_name: BTB_SANBR
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11822
counters:
  proteins: 1467
  matches: 1469
  proteomes: 934
  taxa: 3290
  structures: 0
  alphafold_models: 1256
  domain_architectures: 29
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021777
description: Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD
  to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain
  found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination
  (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR
  [[cite:PUB00099259]].