id: Pfam:PF11825
pfam_id: PF11825
name: Nuclear/hormone receptor activator site AF-1
short_name: Nuc_recep-AF1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11825
counters:
  proteins: 3896
  matches: 3914
  proteomes: 744
  taxa: 2283
  structures: 5
  alphafold_models: 3578
  domain_architectures: 16
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021780
description: Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like
  other transcription factors, they contain a distinct DNA binding domain that allows for target gene
  recognition and several activation domains that possess the ability to activate transcription [[cite:PUB00063250]].
  One of these activation domains is at the N-terminal, although there are two distinct motifs within
  this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding
  regions. One of the co-activators is TIF1beta, which appears to bind at the first motif [[cite:PUB00063251]].