id: Pfam:PF11846
pfam_id: PF11846
name: Virulence factor membrane-bound polymerase, C-terminal
short_name: Wzy_C_2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11846
counters:
  proteins: 1437
  matches: 1437
  proteomes: 1263
  taxa: 1732
  structures: 0
  alphafold_models: 859
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021797
description: Wzy is a membrane-bound polymerase of 12 TMs, found in Gram-positive bacteria such as Streptococcus
  pnuemoniae. It forms part of the EPS or exopolysaccharide system. This family is the 6xTMs at the C-terminal
  end of the molecule. Wzy functions in polymerizing the oligosaccharide repeat subunits to form high-molecular-weight
  capsular polysaccharides. A contiguous emebrane-bound flippase, Wzx, [pfam:PF01943], transports the
  repeat units to the external surface of the membrane. These polysaccharides form the capsule and their
  differing compositions contribute to the multidudinous pneumococcal capsular serotypes, all being structurally
  and antigenically different [[cite:PUB00075665]].