id: Pfam:PF11847
pfam_id: PF11847
name: Alpha-(1->3)-arabinofuranosyltransferase, N-terminal GT-C domain
short_name: GT-C_AftD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11847
counters:
  proteins: 1673
  matches: 1717
  proteomes: 1560
  taxa: 1916
  structures: 3
  alphafold_models: 161
  domain_architectures: 18
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021798
description: This domain is found at the N-terminal end of alpha-(1->3)- arabinofuranosyltransferase from
  Mycolicibacterium smegmatis (AftD, [ec:2.4.2.47]), which is involved in the biosynthesis of the arabinogalactan
  (AG) region of the mycolylarabinogalactan -peptidoglycan (mAGP) complex, an essential component of the
  mycobacterial cell wall. It catalyses the addition of an arabinofuranosyl (Araf) residue from the sugar
  donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan
  backbone of AG [[cite:PUB00086410]]. This domain shows mixed alpha/beta folds homologous to other solved
  GT-C glycosyltransferase structures [[cite:PUB00155574]].