id: Pfam:PF11861
pfam_id: PF11861
name: Ribosomal RNA methyltransferase Spb1, DUF3381
short_name: DUF3381
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11861
counters:
  proteins: 3891
  matches: 3912
  proteomes: 3174
  taxa: 8437
  structures: 35
  alphafold_models: 3292
  domain_architectures: 77
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024576
description: This domain is functionally uncharacterised and it is found in the central region of fungal
  SPB1 and mammalian homologue FTSJ3. This domain is found associated with [pfam:PF07780], [pfam:PF01728].
  SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles
  during the biogenesis of the 60S ribosomal subunit [[cite:PUB00016377]]. FTSJ3, SPB1 homologue in humans,
  is associated with NIP7 (involved in the biogenesis of 40S subunit) and functions in pre-rRNA processing
  [[cite:PUB00068805]].