id: Pfam:PF11865
pfam_id: PF11865
name: Serine/threonine-protein kinase mTOR domain
short_name: mTOR_dom
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11865
counters:
  proteins: 4633
  matches: 4788
  proteomes: 3091
  taxa: 8323
  structures: 42
  alphafold_models: 284
  domain_architectures: 202
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024585
description: This entry represents a domain found in human serine/threonine-protein kinase mTOR and its
  homologues, a central regulator of cellular metabolism, growth and survival in response to hormones,
  growth factors, nutrients, energy and stress signals [[cite:PUB00151556],[cite:PUB00151557],[cite:PUB00151558],[cite:PUB00151559],[cite:PUB00151555]].
  In Saccharomyces cerevisiae, the TOR proteins, TOR1 and TOR2, regulate growth in a rapamycin-sensitive
  manner [[cite:PUB00015261]]. This domain consists of HEAT repeats [[cite:PUB00103870],[cite:PUB00151560]].