id: Pfam:PF11873
pfam_id: PF11873
name: Membrane-bound lytic murein transglycosylase C, N-terminal domain
short_name: Mltc_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11873
counters:
  proteins: 1266
  matches: 1266
  proteomes: 1161
  taxa: 1815
  structures: 4
  alphafold_models: 845
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024570
description: This domain is found associated with [pfam:PF01464]. It is the N-terminal structural domain
  of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found
  in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is
  suggested to be important not as a mere structural extension of the active site beyond what is seen
  in other lytic transglycosylases but one that creates a peptide-binding site at position +2 [[cite:PUB00109606]].