id: Pfam:PF11878
pfam_id: PF11878
name: Dedicator of cytokinesis C/D, N terminal
short_name: DOCK_C-D_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11878
counters:
  proteins: 12034
  matches: 12101
  proteomes: 1245
  taxa: 4049
  structures: 7
  alphafold_models: 701
  domain_architectures: 119
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021816
description: 'This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D
  subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange
  factors (GEFs) for Rho-family GTPases [[cite:PUB00014935],[cite:PUB00073863]], required during several
  cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorised into four
  subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4),
  DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [[cite:PUB00014935]].'