id: Pfam:PF11901
pfam_id: PF11901
name: DM9 repeat
short_name: DM9
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11901
counters:
  proteins: 4828
  matches: 5400
  proteomes: 1163
  taxa: 3688
  structures: 10
  alphafold_models: 4123
  domain_architectures: 195
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006616
description: This repeat of unknown function was first identified in Diptera proteins; later on it was
  found in a wide range of invertebrates and vertebrates [[cite:PUB00101198]], such as natterin [[cite:PUB00056184],[cite:PUB00101201]].
  It is often present in proteins comprising only two or four DM9 repeats and occasionally is linked to
  other domains at its N- or C-terminal. In the mannose-specific lectin CGL1 from Crassostrea gigas, DM9
  exhibits high binding specificity and avidity toward D-mannose residue and served as a pattern recognition
  receptor (PRR) with a broad range of recognition spectrum to various pathogen-associated molecular patterns
  [[cite:PUB00101199]]. It also mediates immune recognition and cellular encapsulation [[cite:PUB00101200]].