id: Pfam:PF11916
pfam_id: PF11916
name: Vacuolar protein 14 C-terminal Fig4p binding
short_name: Vac14_Fig4_bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11916
counters:
  proteins: 4615
  matches: 4765
  proteomes: 3255
  taxa: 8564
  structures: 0
  alphafold_models: 3826
  domain_architectures: 86
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021841
description: 'Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion
  of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the
  cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least
  five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p,
  the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p.
  The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein
  carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is
  crucial for the proper functioning of the mammalian nervous system.'