id: Pfam:PF11918
pfam_id: PF11918
name: N-terminal domain of Peptidase_S41 in eukaryotic IRBP
short_name: Peptidase_S41_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11918
counters:
  proteins: 2795
  matches: 5620
  proteomes: 1612
  taxa: 4894
  structures: 4
  alphafold_models: 2003
  domain_architectures: 56
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
description: Peptidase_S41_N is a family found at the N-terminus of the functional unit of interphotoreceptor
  retinoid binding proteins 3, IRBP, in eukaryotes. From the structure of PDB:1j7x, the domain forms the
  N-terminal end of the module which is characterised as a serine-peptidase, [pfam:PF03572]. Peptidase_S41_N
  forms a three-helix bundle followed by a small beta strand and is termed domain A. Part of the peptidase
  domain folds back over domain A to create a largely hydrophobic cleft between the two domains. On binding
  of ligand domain A is structurally rearranged with respect to domain B [[cite:PUB00026288]].