id: Pfam:PF11919
pfam_id: PF11919
name: Proteasome activator complex subunit 4-like, C-terminal
short_name: PSME4_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11919
counters:
  proteins: 4775
  matches: 4782
  proteomes: 3014
  taxa: 7986
  structures: 9
  alphafold_models: 412
  domain_architectures: 74
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021843
description: This domain is found at the C-terminal end of human Proteasome activator complex subunit
  4 (PSME4) and similar sequences from eukaryotes. PSME4 is an associated component of the proteasome
  that specifically recognises acetylated histones and promotes ATP- and ubiquitin -independent degradation
  of core histones during spermatogenesis and DNA damage response. This protein adopts a dome-like structure
  composed of HEAT repeat-like modules and a C-terminal domain that contains a hydrophobic -tyrosine-other
  motif (this entry). This domain, which adopts an all-alpha structure, is responsible for the interaction
  with the alpha-ring surface of the 20S [[cite:PUB00155659]].