id: Pfam:PF11927
pfam_id: PF11927
name: Haem-dependent oxidative N-demethylase, alpha subunit-like
short_name: HODM_asu-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11927
counters:
  proteins: 6200
  matches: 6341
  proteomes: 3026
  taxa: 5492
  structures: 3
  alphafold_models: 4748
  domain_architectures: 88
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021848
description: This protein family is found in fungi and bacteria, including the alpha subunit of an haem-dependent
  oxidative N-demethylase (HODM) from Pseudomonas mendocina. This protein, catalytically active, is responsible
  for haem, oxygen and NADPH-dependent dimethylamine (DMA) binding. It shows structural similarity to
  the to the Aer2 PAS domain, but lacks the core PAS-domain alpha-helix that forms the Aer2 haem pocket,
  and displays extended beta-strands and a longer loop [[cite:PUB00100877]]. The structure of [swissprot:A4XXY9],
  PDBe:5lte, shows that it is an haem-binding PAS domain, similar in structure to PAS gas sensors [[cite:PUB00100877]].