id: Pfam:PF11928
pfam_id: PF11928
name: Early growth response N-terminal domain
short_name: DUF3446
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11928
counters:
  proteins: 2563
  matches: 2576
  proteomes: 717
  taxa: 2470
  structures: 2
  alphafold_models: 2221
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021849
description: Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1
  is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites
  that can potentially be methylated at four cytosine bases [[cite:PUB00086408]]. EGR2, also known as
  Krox20, is an E3 ligase that sumoylates its Nab coregulators [[cite:PUB00086407]]. This domain has a
  single completely conserved residue P that may be functionally important. Furthermore, it is found associated
  with [pfam:PF00096].