id: Pfam:PF11935
pfam_id: PF11935
name: Symplekin/PTA1 N-terminal
short_name: SYMPK_PTA1_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11935
counters:
  proteins: 4626
  matches: 4686
  proteomes: 2872
  taxa: 7645
  structures: 18
  alphafold_models: 3038
  domain_architectures: 70
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR032460
description: This is the N-terminal domain found in the symplekin protein from animals and PTA1 protein
  from budding yeasts and is typically between 239 to 261 amino acids in length. Symplekin is a scaffold
  protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing
  [[cite:PUB00068954],[cite:PUB00068955]]. PTA1 is involved in pre-tRNA processing. PTA1 is a subunit
  of the cleavage and polyadenylation factor (CPF), which plays a key role in polyadenylation-dependent
  pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB
  [[cite:PUB00070276]]. This domain has the ARM or HEAT fold, with seven pairs of antiparallel alpha-helices
  arranged in the shape of an arc. It is important for interaction with Ssu72 and stimulates Ssu72 C-terminal
  domain phosphatase activity in vitro [[cite:PUB00065426]].