id: Pfam:PF11938
pfam_id: PF11938
name: TLR4 regulator and MIR-interacting MSAP
short_name: DUF3456
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11938
counters:
  proteins: 6340
  matches: 7021
  proteomes: 1740
  taxa: 5435
  structures: 1
  alphafold_models: 5514
  domain_architectures: 121
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021852
description: This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated
  with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition
  of microbial products, the first line of defence against bacterial infection [[cite:PUB00109675]]. PRAT4A
  influences the subcellular distribution and the strength of TLR responses and alters the relative activity
  of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression
  there [[cite:PUB00109676]][[cite:PUB00109677]]. TLR4 recognizes lipopolysaccharide (LPS), one of the
  most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This
  family has also been described as a SAP-like MIR-interacting protein family.