id: Pfam:PF11963
pfam_id: PF11963
name: Betacoronavirus, lineage A, NSP1
short_name: B-CoV_A_NSP1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11963
counters:
  proteins: 165
  matches: 184
  proteomes: 6
  taxa: 73
  structures: 0
  alphafold_models: 11
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022570
description: This family the N-terminal region of the Betacoronavirus polyprotein which contains non-structural
  protein 1 (Nsp1) from Betacoronavirus lineage A. This protein is important for viral replication and
  pathogenesis [[cite:PUB00094116],[cite:PUB00097618]]. It suppresses the host innate immune functions
  by inhibiting type I interferon expression and host antiviral signalling pathways.