id: Pfam:PF11996
pfam_id: PF11996
name: Lymphostatin, delivery I domain
short_name: Lymphostatin_delI
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11996
counters:
  proteins: 44
  matches: 50
  proteomes: 19
  taxa: 75
  structures: 5
  alphafold_models: 10
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021882
description: This entry represents the first region from the so-called delivery domain from Lymphostatin.
  Lymphostatin is a key virulence factor of enteropathogenic and enterohaemorrhagic Escherichia coli,
  playing roles in bacterial colonisation of the gut and in the inhibition of lymphocyte proliferation
  and proinflammatory responses [[cite:PUB00164033]]. Lymphostatin is composed of six distinct domains
  which enable complex interactions with host cells. These domains include two glycosyltransferase domains,
  one PaToxP-like protease domain, an ADP-ribosyltransferase domain, a vertex domain and a delivery domain
  [[cite:PUB00164033]]. The delvery domain is involved in the receptor binding and translocation. It is
  an evolutionary conserved translocation and delivery apparatus in LCT-like toxins [[cite:PUB00164033]].
  The delivery domain shows some flexibility and can adopt different conformations.