id: Pfam:PF11999
pfam_id: PF11999
name: Ice-binding-like
short_name: Ice_binding
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11999
counters:
  proteins: 2322
  matches: 2427
  proteomes: 1257
  taxa: 2377
  structures: 25
  alphafold_models: 1582
  domain_architectures: 158
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021884
description: This family includes members found in bacteria, fungi and archaea, many of which are ice-binding
  proteins (IBPs) [[cite:PUB00094907]]. In Antarctic bacterium Flavobacterium frigoris PS1, FfIBP is an
  ice-binding protein that inhibits ice growth through direct interaction with ice crystals to permit
  the survival of polar organisms in extremely cold environments [[cite:PUB00089804]]. In arctic yeast
  Leucosporidium sp, LeIBP, an ice-binding protein, can lower the freezing point below the melting point
  once it binds to ice [[cite:PUB00058444]]. Family members also have a single completely conserved glycine
  residue that may be functionally important.