id: Pfam:PF12011
pfam_id: PF12011
name: RNA helicase NPH-II
short_name: NPH-II
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12011
counters:
  proteins: 59
  matches: 59
  proteomes: 52
  taxa: 156
  structures: 0
  alphafold_models: 50
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021892
description: RNA helicase NPH-II or I8 is found in Poxviridae. It is essential for viral replication and
  plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation
  behind the elongating RNA polymerase. It acts as NTP-dependent helicase that catalyzes unidirectional
  unwinding of 3'tailed duplex RNAs. It might also play a role in the export of newly synthesized mRNA
  chains out of the core into the cytoplasm and is required for propagation of viral particles [[cite:PUB00053892]].