id: Pfam:PF12018
pfam_id: PF12018
name: Domain of unknown function
short_name: FAP206
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12018
counters:
  proteins: 1601
  matches: 1641
  proteomes: 1224
  taxa: 4024
  structures: 1
  alphafold_models: 1404
  domain_architectures: 28
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021897
description: 'This domain of about 280 residues is found in eukaryotes. There are two conserved sequence
  motifs: GFC and GLL. This family is also known as UPF0704. This domain is found FAP206 [swissprot:Q23H79],
  a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes,
  each of which is a macromolecular complex essential for motility. A triplet of three radial spokes,
  RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct
  base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206
  gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part
  of the front prong and docks RS2 and dynein c to the microtubule [[cite:PUB00082324]].'