id: Pfam:PF12022
pfam_id: PF12022
name: COG complex component, COG2, C-terminal
short_name: COG2_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12022
counters:
  proteins: 3152
  matches: 3267
  proteomes: 2247
  taxa: 6622
  structures: 0
  alphafold_models: 2684
  domain_architectures: 68
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024603
description: The COG complex comprises eight proteins (COG1-8) and plays critical roles in Golgi structure
  and function [[cite:PUB00012274]]. It is necessary for retrograde trafficking in the Golgi apparatus
  and for protein glycosylation [[cite:PUB00097774]]. COG complex, together with exocyst, Golgi-associated
  retrograde protein (GARP) and Dsl1 complexes, is a member of the CATHR (complexes associated with tethering
  containing helical rods) family sharing an evolutionary origin and structural features [[cite:PUB00100047]].
  This domain represents the C-terminal of COG complex subunit 2 and consists of a conserved alpha-helical
  bundle. In Arabidopsis, COG2 forms a complex with FPP3/VETH1 and FPP2/VETH2 and ensures the correct
  secondary cell wall (SCW) deposition pattern by recruiting exocyst components to cortical microtubules
  in xylem cells during secondary cell wall deposition [[cite:PUB00097774]].