id: Pfam:PF12026
pfam_id: PF12026
name: Crk-Associated Substrate C-terminal domain
short_name: CAS_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12026
counters:
  proteins: 4918
  matches: 4939
  proteomes: 1182
  taxa: 3860
  structures: 2
  alphafold_models: 4372
  domain_architectures: 44
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021901
description: This is a C-terminal domain found in CAS family members. The CAS (Crk-Associated Substrate)
  protein family is a group of scaffolding proteins that play important modulatory roles in both normal
  and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain [pfam:PF00018]
  and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated
  by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk,
  Crk-L, CRKII presumed domain is functionally uncharacterised [[cite:PUB00069470]].