id: Pfam:PF12031
pfam_id: PF12031
name: SWI/SNF-like complex subunit BAF250/Osa
short_name: BAF250_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12031
counters:
  proteins: 4970
  matches: 5040
  proteomes: 1548
  taxa: 4911
  structures: 6
  alphafold_models: 629
  domain_architectures: 26
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR033388
description: This entry represents the mammalian BAF250a/b and its homologue osa from fruit flies [[cite:PUB00071661]].
  They are part of the SWI/SNF-like ATP-dependent chromatin remodelling complex that regulates gene expression
  through regulating nucleosome remodelling. In humans there are two BAF250 isoforms, BAF250a/ARID1a and
  BAF250b/ARID1b. BAF250a/b may be E3 ubiquitin ligases that target histone H2B [[cite:PUB00071658]].