id: Pfam:PF12038
pfam_id: PF12038
name: tRNA-queuosine alpha-mannosyltransferase N-terminal
short_name: QTMAN_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12038
counters:
  proteins: 2272
  matches: 2313
  proteomes: 1429
  taxa: 4073
  structures: 0
  alphafold_models: 1894
  domain_architectures: 21
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022701
description: 'This is the N-terminal domain of tRNA-queuosine alpha-mannosyltransferase (QTMAN, also known
  as GTDC1) from animals. QTMAN is a glycosyltransferase that specifically catalyses mannosylation of
  cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)) to form mannosyl-queuosine(34)
  [[cite:PUB00153407]]. Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation
  at cognate codons GAC and GAU, thereby regulating protein translation [[cite:PUB00153407]]. This domain
  is about 170 amino acids in length and adopts a Rossmann-fold. This domain is found associated with
  [pfam:PF00534] found at the C-terminal. This domain has two conserved sequence motifs: HENQ and FNS
  and it also has a single completely conserved residue S that may be functionally important. This domain
  is also found in uncharacterised bacterial sequences.'