id: Pfam:PF12057
pfam_id: PF12057
name: BCL2-associated athanogene 6
short_name: BAG6
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12057
counters:
  proteins: 2436
  matches: 2442
  proteomes: 725
  taxa: 2709
  structures: 0
  alphafold_models: 1779
  domain_architectures: 23
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021925
description: This domain is found in large proline-rich protein BAG6 protein. It has a conserved SDL sequence
  motif. Human BAG6 is an ATP-independent molecular chaperone preventing the aggregation of misfolded
  and hydrophobic patches-containing proteins [[cite:PUB00086005]]. It functions as part of a cytosolic
  protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble
  state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote
  their sorting to the proteasome where they undergo degradation [[cite:PUB00086005],[cite:PUB00086006],[cite:PUB00086007],[cite:PUB00086008]].