id: Pfam:PF12058
pfam_id: PF12058
name: PII-interacting protein X
short_name: PipX
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12058
counters:
  proteins: 248
  matches: 248
  proteomes: 237
  taxa: 642
  structures: 5
  alphafold_models: 147
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021926
description: This protein family includes PII-interacting protein X (PipX) from Synechococcus elongatus
  and similar proteins found in cyanobacteria. PipX modulates the expression of genes involved in nitrogen
  assimilation by interacting with the global nitrogen transcription factor NtcA and the signal transduction
  protein PII. It is involved in several regulatory pathways [[cite:PUB00100697]]. The crystal structure
  of this protein shows a tudor-like domain (TLD), formed by a highly bent beta-sheet that mediates the
  interactions with both PII and NtcA, and two C-terminal helices [[cite:PUB00054483]].