id: Pfam:PF12064
pfam_id: PF12064
name: Protein kinase C-binding protein 1
short_name: DUF3544
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12064
counters:
  proteins: 3284
  matches: 3369
  proteomes: 702
  taxa: 2145
  structures: 0
  alphafold_models: 2827
  domain_architectures: 30
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021931
description: This is a domain found predominantly in eukaryotes and associated with [pfam:PF00628] [pfam:PF01753]
  [pfam:PF00439] [pfam:PF00855]. Family members include protein kinase C-binding protein 1 (also known
  as ZMYND8) which acts as a transcriptional corepressor of the H3K4 demethylase JARID1D [[cite:PUB00085454]].
  ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) binds acetylated damaged
  chromatin, including actively transcribed regions, as a means of recruiting the nucleosome remodeling
  and histone deacetylation (NuRD) chromatin remodeling complex for transcriptional repression and DNA
  double-strand break (DSB) repair by homologous recombination (HR) [[cite:PUB00103635]].