id: Pfam:PF12066
pfam_id: PF12066
name: SERRATE/Ars2, N-terminal domain
short_name: SERRATE_Ars2_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12066
counters:
  proteins: 4526
  matches: 4550
  proteomes: 2693
  taxa: 7319
  structures: 7
  alphafold_models: 3779
  domain_architectures: 74
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021933
description: This domain can be found in the N terminus of the SERRATE (SE) from plants and its homologue,
  Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding
  complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent
  manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found
  in metazoans and S. pombe [[cite:PUB00090022]]. This domain has two completely conserved Y residues
  that may be functionally important.