id: Pfam:PF12070
pfam_id: PF12070
name: Protein SCAI
short_name: SCAI
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12070
counters:
  proteins: 3464
  matches: 3823
  proteomes: 1682
  taxa: 5209
  structures: 0
  alphafold_models: 2971
  domain_architectures: 51
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022709
description: SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF
  transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate
  cell migration through transcriptional regulation of ITGB1 [[cite:PUB00068364]].