id: Pfam:PF12074
pfam_id: PF12074
name: Generalcontrol nonderepressible 1 (Gcn1) N-terminal
short_name: Gcn1_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12074
counters:
  proteins: 1481
  matches: 1535
  proteomes: 1427
  taxa: 2988
  structures: 15
  alphafold_models: 37
  domain_architectures: 138
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022716
description: This entry represents a set of three HEAT repeats found towards the N-terminal region of
  Gcn1 protein, which acts as a translation activator that mediates translational control by regulating
  Gcn2 kinase activity [[cite:PUB00042775]]. It is a ribosome collision sensor that activates a translation
  quality control pathway when a ribosome has stalled during translation [[cite:PUB00159899]].