id: Pfam:PF12102
pfam_id: PF12102
name: MrcB-like, N-terminal domain
short_name: MrcB_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12102
counters:
  proteins: 787
  matches: 790
  proteomes: 748
  taxa: 1530
  structures: 13
  alphafold_models: 479
  domain_architectures: 38
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021961
description: This model describes the N-terminal domain of a group of mostly uncharacterised proteins,
  including 5-methylcytosine-specific restriction enzyme B (also known as MrcB) from E. coli. MrcB recognises
  N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines) produced by a broad range of DNA methylases
  and appears to act against 5-methylcytosine preceded by a purine residue [[cite:PUB00070724]]. The N-terminal
  domain of MrcB has been shown to be a DNA-binding domain, and the crystal structure has been solved
  [[cite:PUB00100346]].