id: Pfam:PF12117
pfam_id: PF12117
name: Parvovirus non-structural protein 1, C-terminal
short_name: NS1_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12117
counters:
  proteins: 186
  matches: 186
  proteomes: 3
  taxa: 49
  structures: 0
  alphafold_models: 5
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021972
description: 'This domain is the transactivation domain of the Parvovirus NS1 protein, located immediately
  C-terminal to the helicase [[cite:PUB00096849],[cite:PUB00083690]]. Parvovirus are some of the smallest
  viruses containing linear, non-segmented single-stranded DNA genomes, with an average genome size of
  5000 nucleotides. They infect a wide range of invertebrates and vertebrates and are well known for causing
  enteric disease in mammals. Genomes contain two large ORFs: NS1 and VP1; other ORFs are found in some
  sub-types and different gene products can arise from splice variants and the use of different start
  codons [[cite:PUB00054921]]. NS1 protein is essential for viral life cycle stages, including DNA replication,
  trans-regulation of the two viral promoters and modulation of heterologous promoters. It exhibits DNA
  binding, endonuclease and helicase activities and is the major contributor to the toxic effect on host
  cells [[cite:PUB00096898]].'