id: Pfam:PF12122
pfam_id: PF12122
name: Cytoplasmic N-terminal domain of rhomboid serine protease
short_name: Rhomboid_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12122
counters:
  proteins: 1303
  matches: 1303
  proteomes: 1267
  taxa: 1789
  structures: 3
  alphafold_models: 811
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022732
description: Rhomboid_N is the N-terminal cytoplasmic domain of the rhomboid intra-membraneous serine
  protease, otherwise known as Peptidase_S54, [pfam:PF01694]. This N-terminal domain has similarity to
  other GlnB-like domains, some of which appear to have a binding role, eg to peptidoglycan. It is not
  clear exactly what the function of this domain is in the protease, but its presence is critical for
  maintaining a catalytically competent state for the protein [[cite:PUB00088222]].