id: Pfam:PF12126
pfam_id: PF12126
name: PML-like, coiled-coil
short_name: PML_CC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12126
counters:
  proteins: 1276
  matches: 1358
  proteomes: 427
  taxa: 1440
  structures: 11
  alphafold_models: 1093
  domain_architectures: 72
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021978
description: This is the coiled-coil region of PML, also known as TRIM19. PML acts in association with
  PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, such as tumour, suppression,
  transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms.
  PML is defined by the TRIM/RBCC motif which consists of an N-terminal RING zinc finger, two BBox type
  zinc fingers followed by a coiled-coil region [[cite:PUB00102048]]. This coiled-coil region is thought
  to mediate interactions with cytomegalovirus IE1 protein and/or other partners [[cite:PUB00102048]].
  This entry also includes RNF207, which has a similar organisation.