id: Pfam:PF12140
pfam_id: PF12140
name: SLED domain
short_name: SLED
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12140
counters:
  proteins: 6903
  matches: 6915
  proteomes: 1228
  taxa: 3976
  structures: 1
  alphafold_models: 6018
  domain_architectures: 97
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021987
description: The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found
  in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing [[cite:PUB00081213]].