id: Pfam:PF12141
pfam_id: PF12141
name: Beta-mannosyltransferases
short_name: BMT
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12141
counters:
  proteins: 525
  matches: 808
  proteomes: 154
  taxa: 389
  structures: 0
  alphafold_models: 429
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021988
description: This entry represents a group of fungal beta-mannosyltransferase that are involved in cell
  wall biosynthesis [[cite:PUB00086020]]. For example, in Candida albicans, BMT1-4 enzymes act stepwise
  to add beta-mannoses on to cell-wall phosphopeptidomannan (PPM). While Bmt5 and Bmt6 are involved in
  the addition of the first and third beta-mans to phospholipomannan (PLM), respectively [[cite:PUB00097617]].
  Furthermore, in Saccharomyces cerevisiae, BMT5 and BMT6 are responsible for methylation of uridine residues
  in the 25S rRNA [[cite:PUB00075659]].