id: Pfam:PF12148
pfam_id: PF12148
name: Tandem tudor domain within UHRF1
short_name: TTD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12148
counters:
  proteins: 2551
  matches: 2573
  proteomes: 973
  taxa: 3282
  structures: 27
  alphafold_models: 2263
  domain_architectures: 42
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021991
description: TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated
  at Lys-9. It specifically recognises H3 tail peptides with the heterochromatin-associated modification
  state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3). This domain is found in eukaryotes
  and is found in association with [pfam:PF00097], [pfam:PF02182], [pfam:PF00628], [pfam:PF00240].