id: Pfam:PF12165
pfam_id: PF12165
name: Alfin
short_name: Alfin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12165
counters:
  proteins: 5069
  matches: 5186
  proteomes: 432
  taxa: 1220
  structures: 5
  alphafold_models: 4174
  domain_architectures: 107
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021998
description: The Alfin family includes PHD finger protein Alfin1 and Alfin1-like proteins. Alfin1 is a
  histone-binding component that specifically recognises H3 tails trimethylated on 'Lys-4' (H3K4me3),
  which marks transcription start sites of virtually all active genes [[cite:PUB00066381],[cite:PUB00066382]].