id: Pfam:PF12172
pfam_id: PF12172
name: ChsH2, rubredoxin-like zinc ribbon domain
short_name: zf-ChsH2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12172
counters:
  proteins: 12165
  matches: 12166
  proteomes: 4066
  taxa: 5926
  structures: 15
  alphafold_models: 7456
  domain_architectures: 44
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022002
description: 'This domain is found at the C-terminal end of the probable enoyl -CoA hydratase alpha subunit
  from Thermomonospora curvata (ChsH2) and similar archaeal and bacterial proteins. ChsH2 is likely to
  be involved in bile acid degradation. The C-terminal region of this protein is organised into two domains:
  an N-terminal zinc finger domain with a three-stranded antiparallel beta-sheet and an N-terminal alpha-helix
  (this entry) and a OB-fold domain ([pfam:PF01796]) [[cite:PUB00155451]]. The domain is duplicated in
  some members like [swissprot:O53566] from M.tuberculosis. The structure of [swissprot:Q97WQ4] from Saccharolobus
  solfataricus reveals two long N-terminal helices followed by a rubredoxin -like zinc ribbon domain represented
  in this family and a C-terminal OB fold domain [[cite:PUB00097287]]. Zinc is chelated by the four conserved
  cysteines in the alignment.'