id: Pfam:PF12257
pfam_id: PF12257
name: Vacuolar membrane-associated protein Iml1, vWA-like domain
short_name: vWA_IML1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12257
counters:
  proteins: 4843
  matches: 4910
  proteomes: 2798
  taxa: 7363
  structures: 15
  alphafold_models: 619
  domain_architectures: 128
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR048255
description: Proteins in this entry contain a DEP domain, which is a globular domain of about 80 residues.
  This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099.
  In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes
  (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy
  [[cite:PUB00063317],[cite:PUB00063319]]. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced
  autophagy [[cite:PUB00063318]]. This is a vWA-like domain.